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Public release date: 18-Feb-2013
Share ] Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Performing sensitive biological experiments is always a delicate affair. Few researchers, however, contend with the challenges faced by Cheryl Nickerson, whose working laboratory aboard the International Space Station (ISS) is located hundreds of miles above the Earth, traveling at some 17,000 miles per hour.
Nickerson, a microbiologist at Arizona State University's Biodesign Institute, is using the ISS platform to pursue new research into the effects of microgravity on disease-causing organisms.
Nickerson presented her research findings and charted the course for future investigations aboard the ISS on February 18 at the 2013 annual meeting for the American Association for the Advancement of Science, held in Boston, Mass. Her talk, entitled "Microgravity: A Novel Tool for Advances in Biomedical Research," is part of a special session devoted to ISS science.
"One important focus of my research is to use the microgravity environment of spaceflight as an innovative biomedical research platform. We seek to unveil novel cellular and molecular mechanisms related to infectious disease progression that cannot be observed here on Earth, and to translate our findings to novel strategies for treatment and prevention."
During an earlier series of NASA space shuttle and ground-based experiments, Nickerson and her team made a startling discovery. Spaceflight culture increased the disease-causing potential (virulence) of the foodborne pathogen Salmonella, yet many of the genes known to be important for its virulence were not turned on and off as expected when this organism is grown on Earth. Understanding how this switching is regulated may be useful for designing targeted strategies to prevent infection.
For NASA, Nickerson's findings were revelatory, given their implications for the health of astronauts on extended spaceflight missions. Already faced with the potential for compromised immunity induced by the rigors of space travel, astronauts may have to further contend with the threat of disease-causing microbes with amped-up infectious abilities. A more thorough understanding of infectious processes and host responses under these conditions is therefore vital for the design of therapeutics and other methods of limiting vulnerability for those on space missions.
The story however, doesn't end there. Further research by Nickerson's team pointed to important implications for the understanding of health and disease on Earth. Her team, including NASA scientists, showed that one of the central factors affecting the behavior of pathogenic cells is the physical force produced by the movement of fluid over a bacterial cell's sensitive surface. This property, known as fluid shear, helps modulate a broad range of cell behaviors, provoking changes in cell morphology, virulence, and global alterations in gene expression, in pathogens like Salmonella.
"There are conditions that are encountered by pathogens during the infection process in the human body that are relevant to conditions that these same organisms experience when cultured in spaceflight. By studying the effect of spaceflight on the disease-causing potential of major pathogens like Salmonella, we may be able to provide insight into infectious disease mechanisms that cannot be attained using traditional experimental approaches on Earth, where gravity can mask key cellular responses," says Nickerson
Nickerson's spaceflight studies also pinpointed an evolutionarily conserved proteincalled Hfqwhich appears to act as a global regulator of gene responses to spaceflight conditions. Further research by her team established that Hfq is a central mediator in the spaceflight-induced responses of other bacterial pathogens, including Pseudomonas aeruginosa, thus representing the first spaceflight-induced regulator acting across bacterial species.
Nickerson's examination of the post-spaceflight alterations in bacterial behavior made use of microarray technology, which allows analysis of gene expression for the entire 4.8 million base pairs found in Salmonella's circular chromosome. Data revealed that 167 distinct genes and 73 proteins had been altered during growth under microgravity conditions, including (but not limited to) virulence-associated genes. Of the 167 genes undergoing up- or down-regulation in response to spaceflight, one third were under the control of the Hfq master regulator protein.
These microgravity studies open a new window into the infectious disease mechanisms of Salmonella, an aggressive pathogen responsible for infecting an estimated 94 million people globally and causing 155,000 deaths annually. In the U.S. alone, more than 40,000 cases of Salmonellosis are reported annually, resulting in at least 500 deaths, and health care costs in excess of $50 million. However, only a small percentage of infections with Salmonella are reported, and the estimated two to four million cases of Salmonella-induced gastroenteritis which occur in the United States each year constitute a significant economic loss of productive work time, reported to exceed $2 billion annually.
While Salmonella has been a pathogen of choice for a broad range of spaceflight investigations, Nickerson stresses that her findings have spaceflight and Earth-based implications. Her confidence is based on her team's work showing that microgravity culture also uniquely alters gene expression and pathogenesis-related responses in other microorganisms.
Nickerson emphasizes that the ISS provides an unprecedented opportunity to study the infection process under microgravity conditions, enabling advances in our understanding of microbial gene expression and accompanying host responses during infection in fine-grained detail. This novel approach holds the potential to identify new classes of genes and proteins associated with infection and disease not possible using traditional experimental conditions on Earth, where the force of gravity can mask certain cellular responses. Further, experiments aboard the ISS will permit the study of microbial transitions and cellular responses to infection over a prolonged time frame - an important advance not available during shuttle-based experiments.
Microgravity research may provide an opportunity to identify novel targets for vaccine development and the Nickerson team, in collaboration with Roy Curtiss, director of the Biodesign Institute's Center for Infectious Diseases and Vaccinology has been working toward this goal. Based on previous findings, the scientists hypothesized that results from microgravity experiments might be used to facilitate vaccine development on Earth.
In a recent spaceflight experiment aboard space shuttle mission STS-135, the team flew a genetically modified Salmonella-based anti-pneumoccal vaccine that was developed in the Curtiss lab. By understanding the effect of microgravity culture on the gene expression and immunogenicity of the vaccine strain, their goal is to genetically modify the strain back on Earth to enhance its ability to confer a protective immune response against pneumococcal pneumonia.
"Recognizing that the spaceflight environment imparts a unique signal capable of modifying Salmonella virulence, we will use this same principle in an effort to enhance the protective immune response of the recombinant attenuated Salmonella vaccine strain," Nickerson says.
Nickerson's space-based microgravity experiments are carried out in conjunction with simultaneous Earth-based controls housed in the same hardware as those in orbit, to compare the behavior of bacterial cells under normal Earth gravity. Additional information is also provided using Earth-based cell cultures which are subjected to a kind of simulated microgravity, produced by culturing cells in a rotating wall vessel bioreactor (RWV), a device designed by NASA engineers to replicate aspects of cell culture in the spaceflight environment.
Back at ASU, RWV reactor experiments were conducted by Nickerson and her team to help confirm that Hfq plays a central regulatory role in the Salmonella response to spaceflight conditions. Nickerson has also used this RWV technology to grow three dimensional (3-D) cell culture models that mimic key aspects of the structure and function of tissues in the body. These 3-D models are being used in the Nickerson lab as human surrogates to provide novel insight into the infectious disease process not obtainable by conventional approaches and for drug/therapeutic testing and development for treatment and prevention.
Nickerson also focuses research efforts on determining the entire repertoire of environmental factors that may influence bacterial response to spaceflight culture. For example, she found that the ion concentration in the cell culture media played a key role in the resulting effect of spaceflight on Salmonella virulence. Using the RWV, she was able to identify specific salts that may be responsible for this effect.
Nickerson's long list of firsts (first study to examine the effect of spaceflight on the virulence of a pathogen, first to obtain the entire gene expression response of a bacterium to spaceflight, first to profile the infection process in human cells in spaceflight, first identification of a spaceflight-responsive global gene regulator acting across bacterial species), will soon be augmented with a new experiment, that will be flown on SpaceX Dragon slated for the ISS later this year. Nicknamed PHOENIX, the project will mark the first time a whole, living organismin this case a nematodewill be infected with a pathogen and simultaneously monitored in real time during the infection process under microgravity conditions.
This and future studies aboard ISS will almost certainly deepen science's understanding of the molecular and cellular cues underlying pathogenic virulence and open a new chapter in the understanding of health and disease to benefit the general public.
"It is exciting to me that our work to discover how to keep astronauts healthy during spaceflight may translate into novel ways to prevent infectious diseases here on Earth," Nickerson says.
###
Written by: Richard Harth
Science Writer: The Biodesign Institute
richard.harth@asu.edu
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 18-Feb-2013 Share ] Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Performing sensitive biological experiments is always a delicate affair. Few researchers, however, contend with the challenges faced by Cheryl Nickerson, whose working laboratory aboard the International Space Station (ISS) is located hundreds of miles above the Earth, traveling at some 17,000 miles per hour.
Nickerson, a microbiologist at Arizona State University's Biodesign Institute, is using the ISS platform to pursue new research into the effects of microgravity on disease-causing organisms.
Nickerson presented her research findings and charted the course for future investigations aboard the ISS on February 18 at the 2013 annual meeting for the American Association for the Advancement of Science, held in Boston, Mass. Her talk, entitled "Microgravity: A Novel Tool for Advances in Biomedical Research," is part of a special session devoted to ISS science.
"One important focus of my research is to use the microgravity environment of spaceflight as an innovative biomedical research platform. We seek to unveil novel cellular and molecular mechanisms related to infectious disease progression that cannot be observed here on Earth, and to translate our findings to novel strategies for treatment and prevention."
During an earlier series of NASA space shuttle and ground-based experiments, Nickerson and her team made a startling discovery. Spaceflight culture increased the disease-causing potential (virulence) of the foodborne pathogen Salmonella, yet many of the genes known to be important for its virulence were not turned on and off as expected when this organism is grown on Earth. Understanding how this switching is regulated may be useful for designing targeted strategies to prevent infection.
For NASA, Nickerson's findings were revelatory, given their implications for the health of astronauts on extended spaceflight missions. Already faced with the potential for compromised immunity induced by the rigors of space travel, astronauts may have to further contend with the threat of disease-causing microbes with amped-up infectious abilities. A more thorough understanding of infectious processes and host responses under these conditions is therefore vital for the design of therapeutics and other methods of limiting vulnerability for those on space missions.
The story however, doesn't end there. Further research by Nickerson's team pointed to important implications for the understanding of health and disease on Earth. Her team, including NASA scientists, showed that one of the central factors affecting the behavior of pathogenic cells is the physical force produced by the movement of fluid over a bacterial cell's sensitive surface. This property, known as fluid shear, helps modulate a broad range of cell behaviors, provoking changes in cell morphology, virulence, and global alterations in gene expression, in pathogens like Salmonella.
"There are conditions that are encountered by pathogens during the infection process in the human body that are relevant to conditions that these same organisms experience when cultured in spaceflight. By studying the effect of spaceflight on the disease-causing potential of major pathogens like Salmonella, we may be able to provide insight into infectious disease mechanisms that cannot be attained using traditional experimental approaches on Earth, where gravity can mask key cellular responses," says Nickerson
Nickerson's spaceflight studies also pinpointed an evolutionarily conserved proteincalled Hfqwhich appears to act as a global regulator of gene responses to spaceflight conditions. Further research by her team established that Hfq is a central mediator in the spaceflight-induced responses of other bacterial pathogens, including Pseudomonas aeruginosa, thus representing the first spaceflight-induced regulator acting across bacterial species.
Nickerson's examination of the post-spaceflight alterations in bacterial behavior made use of microarray technology, which allows analysis of gene expression for the entire 4.8 million base pairs found in Salmonella's circular chromosome. Data revealed that 167 distinct genes and 73 proteins had been altered during growth under microgravity conditions, including (but not limited to) virulence-associated genes. Of the 167 genes undergoing up- or down-regulation in response to spaceflight, one third were under the control of the Hfq master regulator protein.
These microgravity studies open a new window into the infectious disease mechanisms of Salmonella, an aggressive pathogen responsible for infecting an estimated 94 million people globally and causing 155,000 deaths annually. In the U.S. alone, more than 40,000 cases of Salmonellosis are reported annually, resulting in at least 500 deaths, and health care costs in excess of $50 million. However, only a small percentage of infections with Salmonella are reported, and the estimated two to four million cases of Salmonella-induced gastroenteritis which occur in the United States each year constitute a significant economic loss of productive work time, reported to exceed $2 billion annually.
While Salmonella has been a pathogen of choice for a broad range of spaceflight investigations, Nickerson stresses that her findings have spaceflight and Earth-based implications. Her confidence is based on her team's work showing that microgravity culture also uniquely alters gene expression and pathogenesis-related responses in other microorganisms.
Nickerson emphasizes that the ISS provides an unprecedented opportunity to study the infection process under microgravity conditions, enabling advances in our understanding of microbial gene expression and accompanying host responses during infection in fine-grained detail. This novel approach holds the potential to identify new classes of genes and proteins associated with infection and disease not possible using traditional experimental conditions on Earth, where the force of gravity can mask certain cellular responses. Further, experiments aboard the ISS will permit the study of microbial transitions and cellular responses to infection over a prolonged time frame - an important advance not available during shuttle-based experiments.
Microgravity research may provide an opportunity to identify novel targets for vaccine development and the Nickerson team, in collaboration with Roy Curtiss, director of the Biodesign Institute's Center for Infectious Diseases and Vaccinology has been working toward this goal. Based on previous findings, the scientists hypothesized that results from microgravity experiments might be used to facilitate vaccine development on Earth.
In a recent spaceflight experiment aboard space shuttle mission STS-135, the team flew a genetically modified Salmonella-based anti-pneumoccal vaccine that was developed in the Curtiss lab. By understanding the effect of microgravity culture on the gene expression and immunogenicity of the vaccine strain, their goal is to genetically modify the strain back on Earth to enhance its ability to confer a protective immune response against pneumococcal pneumonia.
"Recognizing that the spaceflight environment imparts a unique signal capable of modifying Salmonella virulence, we will use this same principle in an effort to enhance the protective immune response of the recombinant attenuated Salmonella vaccine strain," Nickerson says.
Nickerson's space-based microgravity experiments are carried out in conjunction with simultaneous Earth-based controls housed in the same hardware as those in orbit, to compare the behavior of bacterial cells under normal Earth gravity. Additional information is also provided using Earth-based cell cultures which are subjected to a kind of simulated microgravity, produced by culturing cells in a rotating wall vessel bioreactor (RWV), a device designed by NASA engineers to replicate aspects of cell culture in the spaceflight environment.
Back at ASU, RWV reactor experiments were conducted by Nickerson and her team to help confirm that Hfq plays a central regulatory role in the Salmonella response to spaceflight conditions. Nickerson has also used this RWV technology to grow three dimensional (3-D) cell culture models that mimic key aspects of the structure and function of tissues in the body. These 3-D models are being used in the Nickerson lab as human surrogates to provide novel insight into the infectious disease process not obtainable by conventional approaches and for drug/therapeutic testing and development for treatment and prevention.
Nickerson also focuses research efforts on determining the entire repertoire of environmental factors that may influence bacterial response to spaceflight culture. For example, she found that the ion concentration in the cell culture media played a key role in the resulting effect of spaceflight on Salmonella virulence. Using the RWV, she was able to identify specific salts that may be responsible for this effect.
Nickerson's long list of firsts (first study to examine the effect of spaceflight on the virulence of a pathogen, first to obtain the entire gene expression response of a bacterium to spaceflight, first to profile the infection process in human cells in spaceflight, first identification of a spaceflight-responsive global gene regulator acting across bacterial species), will soon be augmented with a new experiment, that will be flown on SpaceX Dragon slated for the ISS later this year. Nicknamed PHOENIX, the project will mark the first time a whole, living organismin this case a nematodewill be infected with a pathogen and simultaneously monitored in real time during the infection process under microgravity conditions.
This and future studies aboard ISS will almost certainly deepen science's understanding of the molecular and cellular cues underlying pathogenic virulence and open a new chapter in the understanding of health and disease to benefit the general public.
"It is exciting to me that our work to discover how to keep astronauts healthy during spaceflight may translate into novel ways to prevent infectious diseases here on Earth," Nickerson says.
###
Written by: Richard Harth
Science Writer: The Biodesign Institute
richard.harth@asu.edu
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-02/asu-iss011813.php
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Scientists picking up signs of water on the moon's surface typically attribute them to deposits left by comets, asteroids and other heavenly objects. But a new analysis of lunar samples brought back to Earth by Apollo astronauts in the early 1970s indicates that the moon's interior may have been a little damp in its early days.
The findings, published online Sunday in the journal Nature Geoscience, support mounting evidence that the moon once contained some "native" water ? throwing a wrench into current beliefs about how Earth's companion formed.
Prevailing theories hold that the moon was created when a Mars-sized body crashed into the young Earth and broke off debris that eventually coalesced into a new entity. In the process, much of the water would have evaporated into space, leaving Earth's new satellite quite arid.
PHOTOS: Images of space
"It's thought that the moon's formation involved the materials getting very hot," said Paul Warren, a UCLA cosmochemist who was not involved in the new study. "It's usually assumed that little water would have survived through that."
Indeed, the samples returned by the Apollo missions that visited the lunar highlands seemed to confirm that Earth's cold, rocky companion was bone-dry, said University of Notre Dame geologist Hejiu Hui, who led the new analysis.
But work in the last five years has challenged that notion, as scientists have used more advanced methods to look for increasingly tiny concentrations of water in glass beads that are thought to have been formed by volcanic eruptions in the moon's early days.
Some experts have argued that those glass beads could have been exposed to alien water sources after they had been ejected from the moon's interior. So Hui and his colleagues decided to look at a type of rock called plagioclase, which is thought to have formed in a magma ocean inside the moon. Although the rocks later floated to the surface to form the crust, they contain a chemical time capsule from inside the young moon.
To further rule out any outside source of water, Hui's team looked past the surface of these rocks and into their centers.
After examining the samples under a microscope equipped with a spectrometer, the researchers found that the rocks contained 6 parts per million of water. That?s drier than an Earth desert, but far more than expected to survive in a rock from the moon's once-molten center.
The samples should have been bone-dry, Hui said, but "somehow we still detect this amount of water, so that makes things interesting."
Based on their measurements, the researchers estimated that the early moon's magma ocean could have contained up to 320 parts per million of water. Once that ocean mostly crystallized, the remaining residues could have had as much as 1.4% water. That could explain the measured water content in lunar rocks, Hui said.
The findings could have interesting implications for theories about how the moon came to be, Warren said.
"It's thought that the moon's formation involved the materials getting very hot, and it's usually assumed that little water would have survived through that," he said. If the new study is right, "It opens up quite a mystery as to how the moon came through what we think was a very hot genesis process with this much water."
The findings also have implications for the moon's geological evolution, Warren said. Researchers have reconstructed the history of the moon's crustal formation while assuming there were negligible amounts of water involved. Now scientists may need to reevaluate some of those ideas.
Knowing how much water there is could be handy for future explorers. "Someday, when we put men on the moon in a more permanent way, we might need that water," Warren said.
amina.khan@latimes.com
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The 120GB Kingston SSDNow V300 Series SV300S3D7 internal solid-state drive (SSD) is priced to appeal to ordinary consumers but with performance that sat at the top of the enthusiasts market not so long ago. With a great price-per-GB ratio and strong performance, the V300 earns our Editors' Choice for budget internal SSDs.
Over the past 18 months, the price of SSDs has fallen dramatically, both in absolute dollars and cost-per-gigabyte. One of the downsides to the trend, however, is that the lower end of the market is flooded with products with very different performance characteristics. Conventional hard drives don't generally have this problem; models from the major manufacturers tend to perform similarly at the same capacity and price point. Kingston's V300 SSD Now family of products is designed to simplify the selection process. All of the drives in this family pair a SandForce SF-2281 controller with Toshiba's most advanced 19nm NAND Flash. Kingston has custom-tuned the firmware for higher performance and assembles the drive itself. Buying wafers directly from Toshiba and doing the back-end processing in-house gives Kingston better control over prices.
The 120GB V300 is available as a standalone drive for $100, or with a bundled desktop upgrade kit for $120. buys a 2.5- 3.5-inch bracket kit, a SATA cable, molex-to-SATA power converter, and a bundled data migration program. For those who need the additional components, $20 is a decent price to pay for the upgrade.
The desktop upgrade kit is priced at $1 per GB, and it hits this mark without compromising on performance. Our review unit was tested using an Asus P877V-Deluxe motherboard with 8GB of DDR3-1600 and an Intel Core i7-3770K CPU. The P877-V Deluxe offers multiple SATA controllers from Intel and Marvell; the V300 was connected to Intel's 6G SATA port.
We compared the 120GB V300 against the older 256GB OCZ Vertex 3, the 256GB Plextor PX-256M5P, and the new 256GB OCZ Vector. The Vertex 3 and V300 use the same SandForce SF-2281 controller. The Plextor PX-256MP uses Marvell's 88SS9187 controller, while the OCZ Vector is equipped with an Indilinx Barefoot 3 chip.
The 256GB Vertex 3 is the primary point of comparison, but since larger SSDs tend to be faster than smaller ones, even this comparison is asking the 120GB V300 to fight above its weight class. Performance data on the Plextor and OCZ Vector drives is provided to highlight the difference between consumer and enthusiast products; the V300 isn't expected to win these comparisons.
In the AS-SSD benchmark test, the Kingston V300's sequential read speed of 471MBps compares well against the scores of the OCZ Vertex 3 (488MBps), Plextor PX-256MP (504MBps) and Vector (509MBps). [[ok to all of these]]Write speeds aren't as strong; the Kingston V300's sequential write performance hits 163MBps, compared to the Vertex 3's 223MBps. The Plextor PX-256MP and OCZ Vector both score well over 400MBps.
SiSoft Sandra's random read/write tests show the Kingston V300 nearly tying the OCZ Vertex 3 in reads (487MBps vs. 506MBps) and surpassing it for writes (177MBps vs. 144MBps). Again, the newer Plextor PX-256MP and OCZ Vector offer substantially better write performance. The Plextor PX-256MP scores 432MBps while the OZC Vector scores 509MBps.
The real-world gap between the drives is significantly smaller than the synthetic tests imply. In PCMark 7, the Kingston V300 scores a respectable 5164. That's only five percent slower than the 256GB Vertex 3's 5430, while the Plextor PX-256MP and OCZ Vector hit 5458 and 5419 respectively. PCMark 7's storage benchmark test measures performance by simulating virus scans, importing photos, launching games, editing movies, and simultaneously playing and recording HD video.
What these results show is that the real-world performance difference between the 120GB V300 and other drives is much smaller than the synthetic tests would indicate. Potential buyers don't need to worry about missing out on the performance that makes SSDs far superior to conventional hard drives.
The Kingston V300 isn't the fastest SSD on the market but it's based on proven technology at a great price point. Currently, 120GB is the sweet spot for entry-level SSDs?customers who opt for smaller 60-90GB SSDs may find their program installations sharply constrained. The firmware issues that plagued the first SSDs equipped with SandForce 2281 controllers have been long since resolved, and the three-year warranty Kingston includes on these products matches the terms offered by other manufacturers.
An SSD upgrade is one of the best ways to breathe new life into an older system with a conventional hard drive. Even older, Intel Core 2 Duo or AMD-based systems that don't support the SATA 6G standard will see a huge speed increase when combined with an SSD. At $100-$120, the Kingston V300 is cheap enough to justify, even in an older box.
Customers who work with non-compressible data or need high write performance will want to consider other options, but such users are a distinct minority (and are likely aware of their own needs already). For the vast majority of users, the SandForce 2281's weak points aren't weak points at all. This is the SSD cautious buyers have been waiting for. It offers excellent performance at a modest price using proven controller technology, from a vendor with decades of experience in the consumer market. As such, it earns out Editors' Choice for budget internal SSDs.
COMPARISON TABLE
Compare the Kingston SSDNow V300 Series SV300S3D7 with several other hard drives side by side.
More hard drive reviews:
??? Kingston SSDNow V300 Series SV300S3D7
??? Western Digital My Book Studio (4TB)
??? LaCie Porsche Design P'9223 Slim
??? Apricorn Velocity Solo X2
??? OCZ Vector Series VTR1-25SAT3-256G
?? more
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/FGSnip-qI6o/0,2817,2415508,00.asp
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Argonne National Laboratory (Argonne) is a nonprofit research laboratory, based in the US. The company is a national laboratories for scientific and engineering research. It conducts research and development programs in areas such as, energy, environment and national security. The laboratory operates and manages scientific and engineering research facilities such as, Advanced Photon Source, Argonne Leadership Computing Facility, Argonne Tandem Linear Accelerator System, Atmospheric Radiation Measurement Climate Research Facility, Center for Nanoscale Materials, Electron Microscopy Center, Structural Biology Center, and Transportation Research and Analysis Computing Center. Argonne is headquartered in Argonne, Illinois, the US.
Full Report Details at
- www.fastmr.com/prod/538365_argonne_national_laboratory_alternati ..
Argonne National Laboratory - Alternative Energy - Deals and Alliances Profile provides you comprehensive data
and trend analysis of the company's Mergers and Acquisitions (M&As), partnerships and financings. The report provides detailed information on Mergers and Acquisitions, Equity/Debt Offerings, Private Equity, Venture Financing and Partnership transactions recorded by the company over a five year period. The report offers detailed comparative data on the number of deals and their value categorized into deal types, sub-sector and regions.GlobalData derived the data presented in this report from proprietary in-house Alternative Energy eTrack deals database, and primary and secondary research.
Scope
* Financial Deals - Analysis of the company's financial deals including M&A, Equity/Debt Offerings, Private Equity, Venture Financing and Partnerships.
* Deals by Year - Chart and table displaying information encompassing the number of deals and value reported by the company by year, for a five year period.
* Deals by Type - Chart and table depicting information including the number of deals and value reported by the company by type such as M&A, Equity/Debt Offering etc.
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* Major Deals - Information on the company's major financial deals. Each such deal has a brief summary, deal type, deal rationale; and deal financials and target Company?s (major public companies) key financial metrics and ratios.
* Business Description - A brief description of the company's operations.
* Key Employees - A list of the key executives of the company.
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* Key Competitors - A list of the key competitors of the company.
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Get detailed information on the company's financial deals that enable you to understand the company's expansion/divestiture and fund requirements
* The profile enables you to analyze the company's financial deals by region, by year, by business segments and by type, for a five year period.
Understand the company's business segments' expansion / divestiture strategy
* The profile presents deals from the company's core business segments' perspective to help you understand its corporate strategy.
Access elaborate information on the company's recent financial deals that enable you to understand the key deals which have shaped the company
* Detailed information on major recent deals includes a summary of each deal, deal type, deal rationale, deal financials and Target Company's key financial metrics and ratios.
Equip yourself with detailed information about the company?s operations to identify potential customers and suppliers.
* The profile analyzes the company's business structure, locations and subsidiaries, key executives and key competitors.
Stay up-to-date on the major developments affecting the company
* Recent developments concerning the company presented in the profile help you track important events.
Gain key insights into the company for academic or business research
* Key elements such as break up of deals into categories and information on detailed major deals are incorporated into the profile to assist your academic or business research needs.
Note*: Some sections may be missing if data is unavailable for the company.
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Source: http://reports.pr-inside.com/new-market-report-now-available-argonne-r3587755.htm
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